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Jing-Sheng Zheng, M.D.

CURRICULUM VITAE

Jing-Sheng Zheng, M.D., Ph.D., F.A.C.C.

2 Sindoni Lane
Hammonton, NJ 08037
Tel (609) 561-8500
Fax (609) 567-0432

PERSONAL DATA

Date of Birth: 1963

EDUCATION

8/1992
Case Western Reserve University
Cleveland, OH
Degree: Ph.D. - Physiology and Biophysics

8/1984
Fujian Medical College
Fuzhou, Fujian, China
Degree: M.D.

POSTGRADUATE TRAINING

7/1983-6/1984
Intern
Shaowu Hospital
Fujian, China

8/1984-1/1987
Cardiologist
Fujian Provincial Cardiovascular Diseases Research Institute and Fujian Provincial Hospital
Fujian, China

Preceptor: Xizhong Hu, M.D., Chairman, Department of Cardiology; Director, Fujian Provincial Research Institute for Cardiovascular Diseases; Professor of Medicine, Fujian Medical College
Fuzhou, Fujian, China

1/1987-5/1992
Graduate Student, Department of Physiology and Biophysics
Case Western University
Cleveland, OH

1/1987-5/1992
Research Assistant, Department of Investigative Medicine
Mt. Sinai Medical Center
Cleveland, OH

7/1996-6/1997
Intern, Department of Internal Medicine
George Washington University - Providence Hospital
Washington, DC (PGY1)

7/1997-6/1998
Resident, Department of Internal Medicine
George Washington University - Providence Hospital
Washington, DC (PGY2)

7/1998-6/1999
Resident, Department of Internal Medicine
George Washington University - Providence Hospital
Washington, DC (PGY3)

7/1999-Present
Cardiology Fellow and Clinical Instructor of Medicine
Department of Medicine
Temple University Hospital
Philadelphia, PA

CERTIFICATION

Chinese National Medical Board
American Board of Internal Medicine
American Board of Internal Medicine, Cardiovascular Diseases
Advanced Cardiac Life Support
Certification Board of Nuclear Cardiology
Certification Board of Echocardiography

HOSPITAL STAFF APPOINTMENTS

AtlantiCare Regional Medical Center
Mainland Campus, Atlantic City Campus, NJ

Our Lady of Lourdes Medical Center
Camden, NJ

Bacharach Institute for Rehabilitation
Pomona, NJ

AWARDS, SCHOLARSHIPS AND HONORS

7/1983 Distinguished Medical Student (top 5%)
Fujian Medical College, Fujian, China

7/1987-6/1990 Research Assistantship from NIH grant

5/1988 Excellent Thesis Award
Chinese Echo-Biomedical Society

7/1990-7/1991 Haas Research Fellowship from Mt. Sinai Hospital
Cleveland, OH

8/1990-6/1992 Research Assistantship from NIH grant

3/1996 On-the-Spot Award
Department of Health and Human Services
Public Health Service, USA

5/1999 Resident Thesis Award, Providence Hospital
George Washington University
Washington, DC

5/1999 Physician Recognition Award
American Medical Association

5/2004 Physician Recognition Award
American Medical Association

2006 America's Top Physicians
Consumers' Research Council of America

9/2012 Top Physician, South Jersey Magazine

PROFESSIONAL AFFILIATIONS

Fellow, American College of Cardiology
Scientific Council Member, American Heart Association
American Medical Association
American College of Cardiology
American College of Physicians
American Society of Nuclear Cardiology
American Society of Echocardiography
Chinese-American Heart Association

PROFESSIONAL ACTIVITIES

6/2000-Present
Guest Professor
Fujian Medical College
Fujian, China

RESEARCH

2010 Sub-investigator, SAVOR
2010 Sub-investigator, SOLID
2012 Sub-Investigator, REVEAL
2012 Sub-Investigator, GLORIA
2013 Sub-Investigator, AMGEN 115
2013 Sub-Investigator, AMGEN 118
2013 Sub-Investigator, DECLARE

INVITED LECTURES

"Regulation of ATP-Induced Ca2+ Response by Protein Kinase A and Protein Kinase C in Adult Myocytes." Gerontology Research Center, National Institute of Aging, National Institutes of Health, October 17, 1991.

"ATP Receptors and Regulation of ATP-Induced Ca2+ Transients in Cardiac Myocytes." Department of Pharmacology, University of California at San Diego, November 25, 1992.

"Signal Transduction by Extracellular ATP in Cardiac Myocytes." Department of Medicine, Washington University, December 22, 1992.

"Atherosclerosis: A Multifactorial Disease." Fujian Provincial Research Institute for Cardiovascular Diseases, Fuzhou, Fujian, China, April 11, 1994.

"Mechanism of Chronic Heart Failure in Hypertrophied Rat." Fujian Provincial Hospital, Fujian, China, April 12, 1994.

"Mechanism of Cardiac Hypertrophy." Annual Conference of Fujian Provincial Research Institute of Cardiovascular Diseases, Fuzhou, Fujian, China, April 13, 1994.

"Intracellular and Molecular Mechanism of Cardiac Hypertrophy and Heart Failure." Department of Medicine, The Affiliated No. 1 Hospital, Xian Medical University, April 18, 1994.

"Alteration of Gene Expression in Chronic Heart Failure Rat." Department of Medicine, Institute of Cardiovascular Disease, Tongji Medical University, April 25, 1994.

"Extracellular ATP Inhibits NE- or PE-Induced Cardiac Hypertrophy in Neonatal Cardiac Myocytes." Department of Biology, Beijing Medical University, April 29, 1994.

"Treatment of Acute Myocardial Infarction." Fujian Medical College and Fujian Union Hospital, April 4, 2001.

"Heart Transplant: Preoperative Selection and Postoperative Management." Fujian Heart Association, China, April 6, 2001.

"Update of Acute Myocardial Infarction Management." Weifang Medical College, Weifang Heart Association, April 17, 2001.

"ACC/AHA Guideline for Management of Acute Myocardial Infarction." Fuzhou Second Hospital, April 24, 2001.

CME LECTURE

"Essential Thrombocytopenia." Department of Medicine, Providence Hospital - George Washington University, September 4, 1997.

GRAND ROUNDS

Atrial Fibrillation Update. Temple University Hospital, Philadelphia, PA, June 19, 2002

PUBLICATIONS

Zhang SS, Zheng JS, Hu XZ, Guo G, Lin HP, Xue BC, Chen TS: "Echocardiographic Characterization of Hypertrophic Cardiomyopathy: A Report of 16 Cases." Thesis Collection in 3rd Session of Cardiovascular Meeting 56-61, 1988

Zheng JS, DeYoung MB, Wiener E, Levy MN, Scarpa A: "Extracellular ATP-Induced Ca2+ Transients in Cardiac Myocytes are Potentiated by an Increase in Cellular cAMP." Ann. N.Y. Acad. Sci. 603:448-451, 1990

Zheng JS, Christie A, DeYoung MB, Levy MONITOR, Scarpa A: "Synergism Between Cyclic AMP and ATP in Signal Transduction in Cardiac Myocytes." Am. J. Physiol. 262 (Cell Physiol.): C128-C135, 1992

Zheng JS: "APT Receptors and Regulation of the ATP-Induced Ca2+ Mobilization Response in Cardiac Myocytes." (Ph.D. Thesis)

Zheng JS, Christie A, Levy MN, Scarpa A: "Ca2+ Mobilization by Extracellular ATP in Rat Cardiac Myocytes: Regulation by Protein Kinase C and A." Am. J. Physiol. 263 (Cell Physiol. 32): C933-C940, 1992

Zheng JS, Christie A, Levy MN, Scarpa A: "Modulation of Two Distinct Currents by Extracellular ATP in Isolated Rat Myocytes." Am. J. Physiol. 264 (Cell Physiol. 33): C1411-C1417, 1993

Zheng JS, Boluyt MO, O'Neill L, Crow MT, Lakatta EG: "Extracellular ATP Induces Immediate-Early Gene Expression but not Cellular Hypertrophy in Neonatal Cardiac Myocytes." Circ. Res. 74:1034-1041, 1994

Zheng JS, Boluyt MO, O'Neill L, Long X, Lakatta EG, Crow MT: "Extracellular ATP inhibits Adrenergic-Induced Hypertrophy of Neonatal cardiac Myocytes." Circ. Res. 78:525-535, 1996

Zheng JS, Boluyt MO, Dai J Li, Long X, Baum B, Lakatta EG Crow MT: "Expression of the AQP-CHIP Water Channel in Rat Heart." Asian Pacific Heart J. 8(1), 1999

Boluyt MO, Zheng JS, Young A, Long X, O'Neill L, Silverman H, Lakatta EG, Crow MT: "Rapamycin Inhibits Cellular Hypertrophy in Cultured Neonatal Rat Cardiac Myocytes." Circ. Res. 81:176-186, 1997

Long X, Boluyt MO, O'Neill L, Zheng JS, Lakatta EG, Crow MT: "Myocardial Retinoid X Receptor, Thyroid Hormone Receptor, and Myosin Heavy Chain Gene Expression in the Rat During Adult." J. Geron. (Biol. Sci) 54A (1): B23-B27, 1999

Long X, Boluyt MO, O'Neill L, Zheng JS, Crow MT, Lakatta EG: "Hypoxia-Induced Expression of Heme Oxygenase Gene in Neonatal Cardiac Myocytes." J. Biol. Chem. (In revision)

Long X, Boluyt MO, Hipolito MDL, Lundberg MS, Zheng JS, O'Neill LO, Cirielli C, Capogrossi M, Lakatta EG, Crow MT: "p53 and the Hypoxia-Induced Apoptosis of Cultured Rat Neonatal Cardiac Myocytes." J. Clin. Invest. 99 (11):2635-2643, 1997

Zheng JS, Boluyt MO, O'Neill L, Long X, Crow MT, Lakatta EG: "Induction of Immediate-Early Genes by Extracellular ATP is Mediated by Activation of P2u-Receptors in the Neonatal Cardiac Fibroblasts." Cardiovasc. Res. 37:718-728, 1998

Boluyt MO, O'Neill L, Zheng JS, Meredith A, Lakatta EG, Crow MT: "Stimulation of Adrenergic Receptor Induces Preproenkephalin Gene Expression in Cardiac Myocytes and Non-Myocytes." (Submitted)

Zheng JS, O'Conor F, Edward EG, Fleg F: "Use Electrocardiogram Stress Test and Thallium Tomography to Predict Cardiac Events in Asymptomatic Volunteers." (In preparation)

Zheng JS, McNeal R, Sangligoli R, Rothman S: "Cardioversion of Atrial Fibrillation in the Patients with Left Ventricular Dysfunction of Heart Failure." (In preparation)

Lin H, Zheng JS, Ukrainski G, Khaw K, Saia J, O'Beirne P, Ewing L, Montilla J, Bousanti C, Wehner LJ, Wrobleski E: "Papillary Fibroelastomas of the Aortic and Tricuspid Valves Mimicking Vegetations in a Patient With Turner Syndrome." Can. Journal of Cardiology 3030:(10):1250, 2014

Lin H, Axelrod H, Khaw K, Ukrainski G, Saia J, O'Beirne P, Ewing L, Montilla J, Bousanti C, Wehner LJ, Wrobleski E, Zheng JS: "A Case Report of Biatrial Recurrence after a Nonfamilial Left Atrial Myxoma Resection." (Submitted)

Lin H, Zheng JS, Khaw K, Ukrainski G, Saia J, O'Beirne P, Ewing L, Bousanti C, Wehner LJ, Wrobleski E: "Using Transesophageal Echocardiogram with Three-Dimensional Reconstruction for Diagnosing Quadricuspid Aortic Valve." (Submitted)

Lin H, Zheng JS, Khaw K, Ukrainski G, Saia J, O'Beirne P, Ewing L, Bousanti C, Wehner LJ, Wrobleski E: "Subaortic Aortic Stenosis with Narrow LVOT - A Case Report and Review." (Submitted)

Gioia G, Zheng JS, Ray A, Gioia M: "Perforated Sinus of Valsalva (PSOV) Aneurysm Closure with a Muscular VSD Occluder. Cardiovas. Revascul. Med. 15(3):165-170, 2014

Lin H, Zheng JS, Khaw K, Wrobleski E, Saia J, Ukrainski G, O'Beirne P, Ewing L, Bousanti C, Wehner LJ: "Right Atrial Cardiac Varix Mimicking Myxoma: Differentiation Using Three-Dimensional Echocardiography." Annals of Thoracic Surgery 97(6), e181, 2014

Hasan R, Saia J, O'Beirne P, Khaw K, Ukrainski G, Ewing L, Bousanti C, Wehner LJ, Wrobleski E, Zheng JS: "A Rare Case Report: Apical Thrombus Mimicking Cardiac Myxoma." Journal of Radiology (Accepted)

Lin X, Axelrod H, Dantas B, O'Beirne P, Khaw K, Wrobleski E, Saia J, Ukrainski G, Ewing L, Bousanti C, Wehner LJ, Zheng JS: "A Rare Case of Subaortic Stenosis." (Submitted)

ABSTRACTS

Zheng JS, DeYoung MB, Levy MN, Scarpa A: "Forskolin and Cyclic AMP Analogues Potentiate ATP-Induced Ca2+ Transients in Myocytes." The Physiologist 32(4): 48, 1989

Christie A, Zheng JS, Levy MN, Scarpa A: "Mechanism of Norepinephrine Enhancement of ATP-Induced Ca2+ Transients." Biophys. J. 57(2):129a, 1990

Zheng JS, Christie A, DeYoung MB, Levy MN, Scarpa A: "Effect of Protein Kinase C Activation on the ATP-Induced Ca2+ Response of Rat Ventricular Myocytes." Biophys. J. 59(2):224a, 1991

Zheng JS, Christie A, Levy MN, Scarpa A: "Extracellular ATP Elicits IATP and Increases ICa Through Different Mechanisms in Rat Ventricular Myocytes." FESAB J. 6(4):A978, 1992

Boluyt MO, O'Neill L, Zheng JS, Meredith A, Lakatta EG, Crow MT: "Adrenergic Receptor stimulation of Preproenkephalin Gene Expression in Cardiac Myocytes and Non-Myocytes." J. Cell. Biochem (Supp.) 17D:227, 1993

Zheng JS, Boluyt MO, O'Neill L, Meredith A, Crow MT, Lakatta EG: "Stimulation of P2 Purinergic Receptors Increases c-fos, c-jun jun-B Gene Expression in Cultured Neonatal Cardiac Ventricular Myocytes." J. Cell. Biochem (Supp.) 17D:235, 1993

Zheng JS, Boluyt MO, Dai YS, Li J, Long XL, Baum BJ, Crow MT: "Expression of CHIP28 Water Channel in Aortic-Constricted Rat Heart." Circulation (Supp.) 88(4):I-232, 1993

Zheng JS, Boluyt MO, Ziman B, Long XL, O'Neill L, Crow MT, Lakatta EG: "Extracellular ATP Induces c-fos Gene Expression via a Ca2+-Dependent Pathway in Cultured Cardiac Myocytes and Fibroblasts." Circulation (Supp.) 88(4):I-92, 1993

Pauly RR, Monticone R, Sollot S, an Lakatta EG, Suzuki T, Crow MT: "The Intracellular Signaling Pathway for the PDGF-Induced Migration of Vascular Smooth Muscle Cells involves Ca2+-Calmodulin-Dependent Protein Kinase II." Circulation (Supp.) 88(4):I-4, 1993

Zheng JS, Boluyt MO, Song L, Adler WH, O'Neill L, Crow MT, Lakatta EG: "Extracellular ATP Activates Multiple Second Messenger Systems and Increases Immediate-Early Gene Expression in Cardiac Fibroblasts." The Physiologist 36:(5) A-15, October 1993

Crow MT, Pauly RR, Zheng JS, Lakatta EG: "The Intracellular Signaling Pathway for Vascular Smooth Muscle Cell Migration in Response to PDGF Involves Calcium/Calmodulin-dependent Protein Kinase II." The Physiologist 36:(5) A-18, October 1993

Zheng JS, Boluyt MO, O'Neill L, Long X, Lakatta EG, Crow MT: "Extracellular Adenosine Triphosphate (ATP) Inhibits Cardiac Myocytes Hypertrophy Induced by Adrenergic Agonist." Circulation (Supp.) 90(4):I-194, 1994

Boluyt MO, Zheng JS, Younes A, O'Neill L, Lakatta EG, Crow MT: "Inhibition of p70 S6 Kinase Inhibits aI-Adrenergic Receptors Stimulated Cardiomyocyte Hypertrophy." (1995 American College of Sports Medicine Annual Meeting)

Zheng JS, Boluyt MO, O'Neill L, Long X, Lakatta EG , Crow MT: "Extracellular ATP is a Potent Inhibitor of Hypertrophy in Neonatal Cardiac Myocytes." (American Heart Association Scientific Conference on the Molecular Cellular and Functional Aspects of Cardiovascular Development, New Orleans, LA, March 1995)

Long X, Boluyt MO, O'Neill L, Zheng JS, Lakatta EG, Crow MT: "Decreased Expression of Retinoid X Receptor Genes Correlates with Age-Associated Changes in Myosin Phenotype in Rat Heart." (American Heart Association Scientific Conference on the Molecular Cellular and Functional Aspects of Cardiovascular Development, New Orleans, LA, March 1995)

Zheng JS, O'Neill L, Long X, Boluyt MO: "Extracellular ATP-Induced c-fos mRNA and Activates Multiple Second Messenger Pathways via P2 Purinergic Receptors in Cardiac Fibroblasts." Circulation (Supp.) 92(8):I-573, 1995

Boluyt MO, Zheng JS, Younes A, O'Neill L, Crow MT: "p70/85 S6 Kinase Activation is Required for aI-Adrenergic Receptors Stimulated Hypertrophy in Neonatal Rat Cardiac Myocytes." Circulation (Supp.) 92(8):I-384, 1995

Boluyt MO, Zheng JS, Younes A, O'Neill L, Lakatta EG, Crow MT: "Rapamycin Selectively Inhibits Protein and RAN Accumulation, but not Induction of Hypertrophy-Associated Genes During Alpha-1 Adrenergic Stimulated Cardiac Myocyte Hypertrophy." Circulation (Supp.) 94(8):I-530, 1996

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